3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

  • Name: 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
  • CAS: 536760-29-9
  • Purity: 99%
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Details

Top quality factory supply 536760-29-9 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one at low price

  • Molecular Formula: C11H9ClN2O3
  • Molecular Weight: 252.6538
  • Boiling Point: 412.167 °C at 760 mmHg 
  • PKA: -5.80±0.40(Predicted) 
  • Flash Point: 203.072 °C 
  • PSA： 66.13000 
  • Density: 1.456 g/cm3 
  • LogP: 3.04240 

3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one(Cas 536760-29-9) Usage

InChI:InChI=1S/C11H9ClN2O3/c12-10-2-1-7-13(11(10)15)8-3-5-9(6-4-8)14(16)17/h2-6H,1,7H2

536760-29-9 Relevant articles

Preparation method of apixaban and intermediates thereof

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Paragraph 0119; 0123, (2018/05/16)

The invention discloses a preparation me...

SOLID STATE FORMS OF APIXABAN

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Paragraph 0036; 0037, (2013/08/28)

The present invention is directed to sol...

Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones

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Page/Page column 12-13, (2010/10/20)

A novel process and intermediates thereo...

536760-29-9 Process route

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
536760-29-9

3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

Conditions
Conditions Yield
With lithium carbonate; lithium chloride; In N,N-dimethyl-formamide; at 105 ℃; for 4h; Green chemistry;
90%
With lithium carbonate; lithium chloride; In N,N-dimethyl-formamide; at 45 - 110 ℃;
With lithium carbonate; In N,N-dimethyl-formamide; at 100 - 105 ℃; for 5h; Inert atmosphere;
257.2 g
5-bromovaleroyl chloride
4509-90-4

5-bromovaleroyl chloride

3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
536760-29-9

3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: water; tetrahydrofuran / 1 h / 20 °C / Green chemistry
1.2: 4 h / 20 °C / Green chemistry
2.1: phosphorus pentachloride / chlorobenzene / 2 h / 53 °C / Green chemistry
3.1: lithium chloride; lithium carbonate / N,N-dimethyl-formamide / 4 h / 105 °C / Green chemistry
With phosphorus pentachloride; lithium carbonate; lithium chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; chlorobenzene;

536760-29-9 Upstream products

  • 881386-01-2
    881386-01-2

    3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

  • 4509-90-4
    4509-90-4

    5-bromovaleroyl chloride

  • 38560-30-4
    38560-30-4

    1-(4-nitrophenyl)piperidine-2-one

  • 100-01-6
    100-01-6

    4-nitro-aniline

536760-29-9 Downstream products

  • 503612-45-1
    503612-45-1

    1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carbonitrile

  • 503614-91-3
    503614-91-3

    1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

  • 536759-91-8
    536759-91-8

    4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo- 1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

  • 1421823-20-2
    1421823-20-2

    ethyl 6-(4-(N-(4-chlorobutyl)carboxamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate

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