Didemnin B

  • Name:Didemnin B
  • CAS:77327-05-0
  • Purity:99%
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1.What is the Didemnin B ?

Used in Anticancer Applications:
Didemnin B is utilized as an anticancer agent, particularly effective against various types of cancer. It has demonstrated the ability to inhibit tumor growth and proliferation by targeting specific cellular pathways and processes, making it a promising candidate for cancer treatment.
Used in Drug Delivery Systems:
To enhance the therapeutic potential and bioavailability of Didemnin B, researchers have developed innovative drug delivery systems. These systems, which may include organic and metallic nanoparticles, aim to improve the delivery and efficacy of Didemnin B, ultimately leading to better treatment outcomes for patients with cancer.

Z-didemnin B
120286-08-0

Z-didemnin B

didemnin B
114607-50-0,128821-14-7,77327-05-0

didemnin B

Conditions
Conditions Yield
With hydrogen; palladium on activated charcoal; In isopropyl alcohol; at 20 ℃; for 2h; under 750.06 Torr;
100%
N-methyl-N-(benzyloxycarbonyl)-D-leucine
65635-85-0

N-methyl-N-(benzyloxycarbonyl)-D-leucine

didemnin B
114607-50-0,128821-14-7,77327-05-0

didemnin B

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1: 91 percent / triphenylphosphine / CH2Cl2 / 1 h / 20 °C
2: 99 percent / 2,4,6-collidine / CH2Cl2 / 2 h / 20 °C
3: 100 percent / hydrogen / 5 percent Pd-C / aq. acetic acid; aq. HCl / 5 h / 20 °C / 750.06 Torr
4: collidine / CH2Cl2 / 2 h
5: 100 percent / hydrogen / 5 percent Pd-C / propan-2-ol / 2 h / 20 °C / 750.06 Torr
With 2,4,6-trimethyl-pyridine; 2,3,5-trimethyl-pyridine; hydrogen; triphenylphosphine; palladium on activated charcoal; In hydrogenchloride; dichloromethane; acetic acid; isopropyl alcohol;
Multi-step reaction with 5 steps
1: 86 percent / triethylamine, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide, DMAP / dimethylformamide / 24 h / Ambient temperature
2: hydrogen / 10percent Pd/C / methanol; ethyl acetate / 15 h / 1810.02 Torr
3: 1.) BOP-Cl, triethylamine / 1.) CH2Cl2, -15 deg C, 30 min, 2.) 0 deg C,
4: tetrabutylammonium fluoride / dimethylformamide; tetrahydrofuran
5: 1.) BOP, N-methylmorpholine / 1.) CH2Cl2, 0 deg C, 30 min, 2.) RT, 3 h
With 4-methyl-morpholine; dmap; tetrabutyl ammonium fluoride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;

2.What is the CAS number for Didemnin B ?

The CAS number of Didemnin B is 77327-05-0.

More information of Didemnin B 77327-05-0 are:

CAS?Number

 77327-05-0

Density

 1.24g/cm3

Boiling Point

 1274.4°C at 760 mmHg

Flash Point

 724.5°C

Vapor Pressure

 0mmHg at 25°C

Refractive Index

 1.6910 (estimate)

PSA

 287.90000

LogP

 3.17870

3.What are another words for Didemnin B ?

Synonyms?for?Didemnin B 77327-05-0:Didemnin A,N-[1-(2-hydroxy-1-oxopropyl)-L-prolyl]-, (S)-;15H-Pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosine, cyclic peptidederiv.; L-Tyrosine,(2S)-2-hydroxypropanoyl-L-prolyl-N-methyl-D-leucyl-L-threonyl-(3S,4R,5S)-4-amino-3-hydroxy-5-methylheptanoyl-(2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoyl-L-leucyl-L-prolyl-N,O-dimethyl-,(9®4)-lactone; NSC 325319; NSC333841

4.What is the molecular formula of Didemnin B?

The chemical formula of ?Didemnin B is?C57H89N7O15 which containing 57 Carbon atoms,89 Hydrogen atoms,7 Nitrogen atoms and 15 Oxygen atoms,and the molecular weight of??Didemnin B?is 1112.37.

5.What is Didemnin B (77327-05-0) used for?

Didemnin B is a natural product that is predominantly found in the marine organisms Lyngbya majuscula and Trididemnum solidum. It is known for its potent bioactive properties and has garnered significant interest in the field of pharmaceutical research.

InChI:InChI=1/C57H89N7O15/c1-15-33(8)46-44(66)29-45(67)79-49(32(6)7)48(68)34(9)50(69)58-39(26-30(2)3)54(73)64-25-17-19-41(64)56(75)62(13)43(28-37-20-22-38(77-14)23-21-37)57(76)78-36(11)47(52(71)59-46)60-51(70)42(27-31(4)5)61(12)55(74)40-18-16-24-63(40)53(72)35(10)65/h20-23,30-36,39-44,46-47,49,65-66H,15-19,24-29H2,1-14H3,(H,58,69)(H,59,71)(H,60,70)/t33-,34-,35-,36+,39-,40-,41?,42+,43-,44-,46+,47-,49-/m0/s1

Relevant articles related to Didemnin B:

Article

Source

Total synthesis of the didemnins; IV. Synthesis of the peptolide ring and construction of the side chain

Schmidt,Kroner,Griesser

, p. 294 - 300 (2007/10/02)

Efficient total synthesis of didemnins A and B

Hamada,Kondo,Shibata,Shioiri

, p. 669 - 673 (2007/10/02)

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