NOMIFENSINE MALEATE

  • Name: NOMIFENSINE MALEATE
  • CAS: 24526-64-5
  • Purity: 99%
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1.What is the NOMIFENSINE MALEATE ?

ChEBI: An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.

Nomifensine is an inhibitor of norepinephrine (NE) and dopamine (DA) reuptake. It inhibits uptake of NE, DA, and serotonin (5-HT) in rat brain synaptosomes with IC50 values of 6.6, 48, and 830 nM, respectively. It is selective for DA, NE, and 5-HT uptake inhibition over binding to dopamine D2, α1- adrenergic-, 5-HT2, and muscarinic receptors (IC50s = 43,000, 1,200, 3,800, and >13,000 nM, respectively, in rat brain membranes). Nomifensine is selective for inhibition of NE over DA uptake in vivo with minimal inhibitory doses of 28 and less than 57 μmol/kg, respectively. It decreases the time Wistar Kyoto, but not Sprague-Dawley, rats spend immobile in the forced swim test but also increases locomotor activity in the open field test in Wistar Kyoto and Sprague-Dawley rats when administered at a chronic dose of 10 mg/kg.

2.What is the CAS number for NOMIFENSINE MALEATE ?

The CAS number of NOMIFENSINE MALEATE is 24526-64-5.

3.What are another words for NOMIFENSINE MALEATE ?

Synonyms?for?NOMIFENSINE MALEATE 24526-64-5:Isoquinoline,8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenyl- (8CI); (?à)-Nomifensin; (?à)-Nomifensine; 2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-ylamine;Linamiphen; Nomifensin; Nomifensine

4.What is NOMIFENSINE MALEATE (24526-64-5) used for?

A novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure.

InChI:InChI=1/C16H18N2/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18/h2-9,14H,10-11,17H2,1H3

Relevant articles related to NOMIFENSINE MALEATE:

Article

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4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors

Pechulis, Anthony D.,Beck, James P.,Curry, Matt A.,Wolf, Mark A.,Harms, Arthur E.,Xi, Ning,Opalka, Chet,Sweet, Mark P.,Yang, Zhicai,Vellekoop, A. Samuel,Klos, Andrew M.,Crocker, Peter J.,Hassler, Carla,Laws, Mia,Kitchen, Douglas B.,Smith, Mark A.,Olson, Richard E.,Liu, Shuang,Molino, Bruce F.

, p. 7219 - 7222 (2013/01/15)

An Improved Synthesis of 8-Amino-2-methyl-4-phenyl-1,2,3,4-Tetrahydroisoquinoline

Ivanov, T. B.,Mondeshka, Diana M.,Angelova, Ivanka G.

, p. 731 - 735 (2007/10/02)

Synthesis and Pharmacological Evaluation of Some New Tetrahydroisoquinoline Derivatives Inhibiting Dopamine Uptake and/or Possessing a Dopaminomimetic Property

Zara-Kaczian, E.,Gyoergy, L.,Deak, G.,Seregi, A.,Doda, M.

, p. 1189 - 1195 (2007/10/02)

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