Dimethyl 2-(2-methoxyphenoxy)malonate
- Name: Dimethyl 2-(2-methoxyphenoxy)malonate
- CAS: 150726-89-9
- Purity: 99%
Details
Cost-effective and customizable Dimethyl 2-(2-methoxyphenoxy)malonate 150726-89-9 in stock
- Molecular Formula: C12H14O6
- Molecular Weight: 254.24
- Appearance/Colour: White solid
- Vapor Pressure: 0mmHg at 25°C
- Refractive Index: 1.497
- Boiling Point: 320.47 °C at 760 mmHg
- PKA: 12.17±0.59(Predicted)
- Flash Point: 138.381 °C
- PSA： 71.06000
- Density: 1.206 g/cm3
- LogP: 0.78860
Dimethyl 2-(2-methoxyphenoxy)malonate(Cas 150726-89-9) Usage
InChI:InChI=1/C12H14O6/c1-15-8-6-4-5-7-9(8)18-10(11(13)16-2)12(14)17-3/h4-7,10H,1-3H3
150726-89-9 Relevant articles
Metabolism study and biological evaluation of bosentan derivatives
Lepri, Susan,Goracci, Laura,Valeri, Aurora,Cruciani, Gabriele
, p. 658 - 670 (2016)
Bosentan, the first-in-class drug used i...
Improved Large-Scale Synthesis of Bosentan Monohydrate
Raju, K. Rajasekhara,Reddy, B. Shankar,Somannavar,Sinha,Babu, P. N. Kishore,Raju, K. Mohana
, p. 481 - 491 (2016/11/09)
-
The discovery of N -[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy] ethoxy]-4-pyrimidinyl]- N ′-propylsulfamide (macitentan), an orally active, potent dual endothelin receptor antagonist
Bolli, Martin H.,Boss, Christoph,Binkert, Christoph,Buchmann, Stephan,Bur, Daniel,Hess, Patrick,Iglarz, Marc,Meyer, Solange,Rein, Josiane,Rey, Markus,Treiber, Alexander,Clozel, Martine,Fischli, Walter,Weller, Thomas
supporting information, p. 7849 - 7861 (2012/10/29)
Starting from the structure of bosentan ...
AN IMPROVED PROCESS FOR THE PREPARATION OF BOSENTAN
-
Page/Page column 19, (2011/04/14)
The present application provides purific...
150726-89-9 Process route
-
-
28868-76-0
2-chlorodimethylmalonate
-
-
90-05-1
2-methoxy-phenol
-
-
150726-89-9
(2-methoxyphenoxy)-malonic acid dimethyl ester
| Conditions | Yield |
|---|---|
|
With
sodium methylate;
In
methanol;
at 45 ℃;
for 1h;
|
78.7%
|
|
2-methoxy-phenol;
With
sodium hydroxide;
In
toluene;
for 2h;
Reflux;
Dean-Stark;
Large scale;
2-chlorodimethylmalonate;
In
toluene;
for 3h;
Reflux;
Large scale;
|
65%
|
|
With
sodium methylate;
In
methanol;
at 20 ℃;
for 20h;
|
|
|
With
sodium;
In
methanol; sodium methylate; toluene;
|
|
|
2-methoxy-phenol;
With
sodium hydroxide;
In
toluene;
at 20 ℃;
Reflux;
2-chlorodimethylmalonate;
In
toluene;
at 60 ℃;
for 3.5h;
Reflux;
|
-
-
38768-62-6
methyl (2-methoxyphenoxy) ethanoate
-
-
616-38-6
carbonic acid dimethyl ester
-
-
150726-89-9
(2-methoxyphenoxy)-malonic acid dimethyl ester
| Conditions | Yield |
|---|---|
|
methyl (2-methoxyphenoxy) ethanoate;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 40 - 45 ℃;
for 5h;
carbonic acid dimethyl ester;
In
tetrahydrofuran; mineral oil;
at 20 - 32 ℃;
for 24h;
|
150726-89-9 Upstream products
-
28868-76-0
2-chlorodimethylmalonate
-
90-05-1
2-methoxy-phenol
-
38768-62-6
methyl (2-methoxyphenoxy) ethanoate
-
616-38-6
carbonic acid dimethyl ester
150726-89-9 Downstream products
-
202288-08-2
5-(2-methoxy-phenoxy)-1H -pyrimidine-4,6-dione
-
329923-15-1
4,6-dihydroxy-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-pyrimidine
-
329924-93-8
5-(o-methoxyphenoxy)-4,6-dihydroxy-2-methyl-pyrimidine
-
150727-22-3
5-(o-methoxyphenoxy)-4,6-dihydroxy-pyrimidine
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